l|_.-~*Paradise2K*~-._|l
Sun, July 16th, 2006, 09:21 AM
Hey all, I'm just going to cut straight to the point.
Link #1: (http://anabolicminds.com/forum/supplements/46205-kidney-trouble-cee-creatine-ethyl-ester.html) The questioning begins.
Link #2: (http://anabolicminds.com/forum/541145-post20.html) Negative reaction.
Link #3: (http://anabolicminds.com/forum/544695-post30.html)
hm, well this is all a bit scary. i had assumed that the safety track record of CEE was sort of equivalent to that of mono. i may rethink my use of CEE after reading this. it just gives a bit of an edge, so why take chances?
Link #4: (http://anabolicminds.com/forum/559959-post34.html)
...
Also, as I was googling this earlier, it seems that your average CEE product already contains a good portion of creatinine in the tub. This is according to the kre alkalyn website and the third party analysis posted on bodybuilding. com. Could ingesting so much creatinine straight off the bat be the culprit of these kidney problems?
Link #5: (http://anabolicminds.com/forum/560686-post38.html)
I found this study while snooping around the FDA website: http://www.fda.gov/ohrms/dockets/doc...-06-vol181.pdf
It details a study in which five subjects were administered 5g of CEE a day. Of the five one developed higher than acceptable serum creatinine levels of 1.7 mg/dl. Not extraordinarily high, but it does give one pause. If an adverse effect occurred in such a small sample size what does that say of the population at large? What would happen with a much larger sample size? I think we are seeing the effects.
There seems to be a lot on the FDA website about CEE. Have a look see if interested. A few papers present data that cast aspersion on the stuff. I won't go there because it is off topic and sure to spark a flame, but much of the data suggests that creatine ethyl ester is at best just crappy monohydrate or at worst mostly ineffective. A total bummer for me. I just bought a kilo in bulk. I guess I'll be tossing it.
Link #6: (http://anabolicminds.com/forum/560706-post42.html) What, by the end of this post, you may be thinking.
Of course what someone decides to put in their own body is their own perogative, but why use CEE at all if the substance has been proven neither safe nor effective? After researching it a bit I feel kind of like a dope for just aimlessly following the crowd. I thought I was already careful, but I think I'll be even more judicious in my supplement use in the future.
Link #7: (http://anabolicminds.com/forum/560833-post47.html) Irony.
Link #8: (http://www.bodybuilding.com/store/ceereport_part1a.jpg) (#1) CEE Product Analysis
Link #9: (http://www.bodybuilding.com/store/ceereport_part1b.jpg) (#1) CEE Analysis Conclusion
Link #10: (http://www.bodybuilding.com/store/ceereport_part2a.jpg) (#2) CEE Product Analysis
Link #11: (http://www.bodybuilding.com/store/ceereport_part2b.jpg) (#2) CEE Analysis Conclusion
Link #12: (http://anabolicminds.com/forum/562229-post52.html)
... BSN has an OK rep, and I would think that their stuff contains near 100% of the reported amount of CEE. But it's possible that Cellmass is impure, and my concentration of CEE has been much lower than I thought. This is one reasonable explaination for my normal serum creatinine levels.
Link #13: (http://anabolicminds.com/forum/562272-post55.html) Another negative reaction.
Link #14: (http://anabolicminds.com/forum/563140-post62.html)
Also, here is a link (http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1955/77/i01/f-pdf/f_ja01606a060.pdf?sessid=6006l3) to a paper published in the 50s that calls into question the validity/legitamacy of the esterfied version of creatine (CEE). Their conclusion is in agreement with the spectrum analysis posted on bodybuilding. com, that CEE is mostly creatinine. It also states that CEE was supposedly created by adding hydrochloric acid to creatine monohydrate. This is interesting because the spectrum analysis I previously posted states that many CEE products are just monohydrate with an acid added. So to sum up this paper, CEE is bogus and has been for a long time.
Digging on search engines, it looks like there is really no hard evidence supporting CEE beyond anecdotal experience. If someone knows any different please feel free to chime in.
Link #15: (http://anabolicminds.com/forum/563409-post64.html)
Wow, that is quite a revealing paper. Being that CEE appears so labile, my guess is that users must really be reporting the effects of just good old creatine mono. Nice find.
Link #16: (http://anabolicminds.com/forum/563908-post68.html)
... But I also have noticed a marked decrease in the retention of water. That is, I have noticibly more definition. So much so that my girlfriend has commented. I didn't realize it was happening while I was taking the stuff, but CEE has to have been the culprit. Regular old mono does the same thing to me, so this too makes me doubt that CEE is really any different than mono. ...
Link #17 (Reference): (http://anabolicminds.com/forum/564159-post70.html)
Link #18: (http://anabolicminds.com/forum/564245-post72.html)
Bruhs,
Good work...this thread is VERY interesting and informative. I feel so enlightened.
I do have an interesting comment though. When I was taking CEE, or what I thought was CEE, I had waaaayyyy less water retention and much more vascularity than with C Mono...so what else could the extras be to produce this. I did notice the diuretic effect when I came off CEE but then again it didn't make me hold that much water to begin with.
I'm confused :confused:
Just a shot in the dark, but could it be because you took less CEE than you did of mono?
...
Link #19: (http://anabolicminds.com/forum/564867-post75.html) Yet another negative reaction.
Link #20: (http://anabolicminds.com/forum/564888-post76.html) Priorities.
Funny thing is yesturday was my second day of the cycle at 2.5g ED of cee. I started feeling the symptoms on day one, but really started feeling the kidney pressure on day two. Then again i seem to be more sensitive to supplements, always having to dose at a lower dose then what's recommended. I too never felt the problems on regular mono, but regular mono never really did anything for me at 10g's ED besides giving me stomach cramps.
Even after only two days of CEE i definitely notice the vascularity difference between being on it and not. But my kidney is numero uno so no more CEE for me. Great discussion.
Link #21: (http://anabolicminds.com/forum/567058-post83.html)
As I said ealier, my blood tests showed my kidney functions to be much better after ending cee for a few days and drinking gallons of water.
When I switched to another form of creatine, like in Pro's "Pump Juice", I had a slight raise in my Cratine level, but no where near as bad as when using CEE.
Bottom line for me: I wont be using any CEE products anymore. I will be using creatine products containing real creatine monohydrate or a few others, like the form found in Pump Juice. I get great results from it and my kidney doesn't seem to suffer! Great product
Pro!
Link #22 (Reference): (http://anabolicminds.com/forum/574352-post86.html)
Link #23: (http://anabolicminds.com/forum/574449-post88.html) Priorities re-visited
...
On a general note - I don't know if this has been stated before in this thread (apologize if it did) but the absorption of CEE is according to the numbers provided in the patent application by the Univ. of Nebraska vastly higher than that of monhydrate (at least 10 times). So if you think you can dose it like mono you might screw yourself.
True, But I have used regular creatine at 20 grams per day with no problem. The CEE gave me trouble at 5 grams per day, so I dropped it to 2-3 grams per day. Still had the same problems with my kidney.
This is a real bummer because I love the pump CEE would give me, especially stacked with a good NO product! But, I guess sacraficing ones kidney is not worth a good pump
Link #24: (http://anabolicminds.com/forum/575327-post94.html) Oh, no! Yes, another negative reaction.
Link #25: (http://anabolicminds.com/forum/575481-post95.html)
...
What I'm saying is that bodybuilders and other sports enthusiasts are trying their hardest to put on muscle, lose fat, and increase endurance by using substances, "supplements", that are, in all effect, completely untested (for efficacy and safety). I'm fairly concerned that there are serious health risks associated with these substances. Maybe this is an old topic of debate, but after reading so many posts about claimed adverse affects from supplements, it kind of gets me thinking.
Does anyone REALLY know WTF even half of these supplements are doing to us in the short-term? Long-term? Short-term, maybe. Long-term, highly doubtful. Sometimes I just think it's stupid that we're jamming all these chemicals into ourselves, blowing wads of money, then reaping a few measly pounds of muscle (if any!). All the while, we may be destorying our livers, kidneys, heart (thermos!), etc.
...
Link #26: (http://anabolicminds.com/forum/575501-post96.html) Hustled?
Well founded points. Risk/reward is skewed. However, I don't think you need to take it to the extreme of anabolic steroids or other illegal supplementation. There are many other time test substances on the market (why protein, creatine monohydrate). Because most of us here demand so much of ourselves, we push what we put in our bodies. This plays into the hands of many supplement providers.
I'm not saying that all supplement providers nor all CEE providers have opportunistic intentions. But many of us curse our lawmakers for taking away a whole class of supplements (PHs) for the purpose of protecting a minority that refused to educate and safeguard itself, while we do the exact such thing with supplements such as CEE. If we provide lip service to the idea of self-regulation, then we should not be surprised when such a privilege is taken away from us. Unfortunately, widespread cynicism is the key. We can't take it for granted when a supplement provider's information regarding the safety of their product is based on an entirely different compound, as it is with CEE. Saying Creatine Ethyl Ester is safe because it is made from Creatine Monohydrate is like saying methanphetamine is safe because it is made from sudafed. IMHO, of course.
Link #27: (http://anabolicminds.com/forum/574727-post91.html) The Clincher.
As I've stated numerous times, I'm no chemist. So you won't find me trying to dicipher the esoteric terminology used in the patent. However, it is clear that the methodology used is based on a previously disproved paper. The patent references and draws heavily on the previous work of Dox and Yoder and their 1922 paper The Esterfication of Creatine. One such example is the following paragraph:
Although the formulation of creatine ethyl ester is disclosed, it should be apparent that a variety of creatine esters may be produced utilizing analogous reaction systems without departing from the spirit and scope of the present invention. See Dox., A.W.; Yoder, L. Esterifcation of Creatine. J. Biol. Chem. 1922, 67,671-673, 20 which is herein incorporated by reference in its entirety. For instance, a variety of methods of producing a creatine ester are contemplated without departing from the spirit and scope of the present invention, such as the methods aud process shown in FIG. 4, wherein X may include a leaving group. Although the use of creatine monohydrate is disclosed, a variety of creatine containing starting compounds are 25 contemplated by the present invention, creatine monohydrate being disclosed merely because of its availability.
The problem lies in the fact that Dox and Yoder were proven wrong over fifty years ago. Dox and Yoder claimed to create creatine ethyl ester but it was proven to be just creatinine. The paper I linked to earlier (Creatine Ethyl Ether BY JAMES D. MOLD, ROBERT C. GORE, JOSEPH M. LYNCH AND E. J. SCHANTZ) itself dismantles Dox and Yoder's work as well as references others who have as well. Here are snippets:
Kapfhammer repeated the preparation of several of these compounds and confirmed the findings of Dox and Yoder. He pointed out, however, that the behavior of these compounds in chemical reactions and toward colorimetric tests and precipitating agents was typical of creatinine and not of creatine.
More.........
Farlane later showed ........ when the chloride was re-moved by shaking creatine methyl ester hydro-chloride with silver carbonate prior to the nitrous acid treatment, only 41y0 of the total nitrogen was evolved, suggesting that a conversion to creatinine may have occurred. Failey and Brand, upon careful electrometric titration of creatine methyl ester hydrochloride with sodium hydroxide, noted an irreversible conversion during the titration, with the end-product giving a titration curve identical to creatinine.
So, I know people will continue using and buying CEE, but I'm quite satisfied that it is bunk now. I have no doubt that the esterfication of creatine would be a boon and would be theoretically superior, but it just doesn't seem to actually have been executed. The fact that the University of Nebraska is involved doesn't impress me either. That's not me being an Ivy League snob, that's me knowing that academics are incredibly fallable. There is a lot to be gained from fudging your lab results.
Overall, given what the patent application contained, I'm not surprised that it was rejected. But does anyone know the exact reason stated for its rejection? I mean, CreaTate is based on dubious science as well, yet it was approved for a patent. How unsubstantiated does something have to be to be outright rejected?
The amount of negative reactions are not limited to the ones I linked to; I only linked to ones that I felt provided the most compelling insight to the individual's case.
Please realize that I'm not saying Creatine Monohydrate is fake, but rather that it is possible that CEE is. With so many people not only on this forum, but in the rest of the health/fitness population in general, I think that if indeed CEE proves to be fake, it could be one of the biggest scams in the history of marketing. Think of what it could mean: kidney problems encountered on a grand scale. That, most definitely, would not be good.
So what do you think? :read::flex:
Link #1: (http://anabolicminds.com/forum/supplements/46205-kidney-trouble-cee-creatine-ethyl-ester.html) The questioning begins.
Link #2: (http://anabolicminds.com/forum/541145-post20.html) Negative reaction.
Link #3: (http://anabolicminds.com/forum/544695-post30.html)
hm, well this is all a bit scary. i had assumed that the safety track record of CEE was sort of equivalent to that of mono. i may rethink my use of CEE after reading this. it just gives a bit of an edge, so why take chances?
Link #4: (http://anabolicminds.com/forum/559959-post34.html)
...
Also, as I was googling this earlier, it seems that your average CEE product already contains a good portion of creatinine in the tub. This is according to the kre alkalyn website and the third party analysis posted on bodybuilding. com. Could ingesting so much creatinine straight off the bat be the culprit of these kidney problems?
Link #5: (http://anabolicminds.com/forum/560686-post38.html)
I found this study while snooping around the FDA website: http://www.fda.gov/ohrms/dockets/doc...-06-vol181.pdf
It details a study in which five subjects were administered 5g of CEE a day. Of the five one developed higher than acceptable serum creatinine levels of 1.7 mg/dl. Not extraordinarily high, but it does give one pause. If an adverse effect occurred in such a small sample size what does that say of the population at large? What would happen with a much larger sample size? I think we are seeing the effects.
There seems to be a lot on the FDA website about CEE. Have a look see if interested. A few papers present data that cast aspersion on the stuff. I won't go there because it is off topic and sure to spark a flame, but much of the data suggests that creatine ethyl ester is at best just crappy monohydrate or at worst mostly ineffective. A total bummer for me. I just bought a kilo in bulk. I guess I'll be tossing it.
Link #6: (http://anabolicminds.com/forum/560706-post42.html) What, by the end of this post, you may be thinking.
Of course what someone decides to put in their own body is their own perogative, but why use CEE at all if the substance has been proven neither safe nor effective? After researching it a bit I feel kind of like a dope for just aimlessly following the crowd. I thought I was already careful, but I think I'll be even more judicious in my supplement use in the future.
Link #7: (http://anabolicminds.com/forum/560833-post47.html) Irony.
Link #8: (http://www.bodybuilding.com/store/ceereport_part1a.jpg) (#1) CEE Product Analysis
Link #9: (http://www.bodybuilding.com/store/ceereport_part1b.jpg) (#1) CEE Analysis Conclusion
Link #10: (http://www.bodybuilding.com/store/ceereport_part2a.jpg) (#2) CEE Product Analysis
Link #11: (http://www.bodybuilding.com/store/ceereport_part2b.jpg) (#2) CEE Analysis Conclusion
Link #12: (http://anabolicminds.com/forum/562229-post52.html)
... BSN has an OK rep, and I would think that their stuff contains near 100% of the reported amount of CEE. But it's possible that Cellmass is impure, and my concentration of CEE has been much lower than I thought. This is one reasonable explaination for my normal serum creatinine levels.
Link #13: (http://anabolicminds.com/forum/562272-post55.html) Another negative reaction.
Link #14: (http://anabolicminds.com/forum/563140-post62.html)
Also, here is a link (http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1955/77/i01/f-pdf/f_ja01606a060.pdf?sessid=6006l3) to a paper published in the 50s that calls into question the validity/legitamacy of the esterfied version of creatine (CEE). Their conclusion is in agreement with the spectrum analysis posted on bodybuilding. com, that CEE is mostly creatinine. It also states that CEE was supposedly created by adding hydrochloric acid to creatine monohydrate. This is interesting because the spectrum analysis I previously posted states that many CEE products are just monohydrate with an acid added. So to sum up this paper, CEE is bogus and has been for a long time.
Digging on search engines, it looks like there is really no hard evidence supporting CEE beyond anecdotal experience. If someone knows any different please feel free to chime in.
Link #15: (http://anabolicminds.com/forum/563409-post64.html)
Wow, that is quite a revealing paper. Being that CEE appears so labile, my guess is that users must really be reporting the effects of just good old creatine mono. Nice find.
Link #16: (http://anabolicminds.com/forum/563908-post68.html)
... But I also have noticed a marked decrease in the retention of water. That is, I have noticibly more definition. So much so that my girlfriend has commented. I didn't realize it was happening while I was taking the stuff, but CEE has to have been the culprit. Regular old mono does the same thing to me, so this too makes me doubt that CEE is really any different than mono. ...
Link #17 (Reference): (http://anabolicminds.com/forum/564159-post70.html)
Link #18: (http://anabolicminds.com/forum/564245-post72.html)
Bruhs,
Good work...this thread is VERY interesting and informative. I feel so enlightened.
I do have an interesting comment though. When I was taking CEE, or what I thought was CEE, I had waaaayyyy less water retention and much more vascularity than with C Mono...so what else could the extras be to produce this. I did notice the diuretic effect when I came off CEE but then again it didn't make me hold that much water to begin with.
I'm confused :confused:
Just a shot in the dark, but could it be because you took less CEE than you did of mono?
...
Link #19: (http://anabolicminds.com/forum/564867-post75.html) Yet another negative reaction.
Link #20: (http://anabolicminds.com/forum/564888-post76.html) Priorities.
Funny thing is yesturday was my second day of the cycle at 2.5g ED of cee. I started feeling the symptoms on day one, but really started feeling the kidney pressure on day two. Then again i seem to be more sensitive to supplements, always having to dose at a lower dose then what's recommended. I too never felt the problems on regular mono, but regular mono never really did anything for me at 10g's ED besides giving me stomach cramps.
Even after only two days of CEE i definitely notice the vascularity difference between being on it and not. But my kidney is numero uno so no more CEE for me. Great discussion.
Link #21: (http://anabolicminds.com/forum/567058-post83.html)
As I said ealier, my blood tests showed my kidney functions to be much better after ending cee for a few days and drinking gallons of water.
When I switched to another form of creatine, like in Pro's "Pump Juice", I had a slight raise in my Cratine level, but no where near as bad as when using CEE.
Bottom line for me: I wont be using any CEE products anymore. I will be using creatine products containing real creatine monohydrate or a few others, like the form found in Pump Juice. I get great results from it and my kidney doesn't seem to suffer! Great product
Pro!
Link #22 (Reference): (http://anabolicminds.com/forum/574352-post86.html)
Link #23: (http://anabolicminds.com/forum/574449-post88.html) Priorities re-visited
...
On a general note - I don't know if this has been stated before in this thread (apologize if it did) but the absorption of CEE is according to the numbers provided in the patent application by the Univ. of Nebraska vastly higher than that of monhydrate (at least 10 times). So if you think you can dose it like mono you might screw yourself.
True, But I have used regular creatine at 20 grams per day with no problem. The CEE gave me trouble at 5 grams per day, so I dropped it to 2-3 grams per day. Still had the same problems with my kidney.
This is a real bummer because I love the pump CEE would give me, especially stacked with a good NO product! But, I guess sacraficing ones kidney is not worth a good pump
Link #24: (http://anabolicminds.com/forum/575327-post94.html) Oh, no! Yes, another negative reaction.
Link #25: (http://anabolicminds.com/forum/575481-post95.html)
...
What I'm saying is that bodybuilders and other sports enthusiasts are trying their hardest to put on muscle, lose fat, and increase endurance by using substances, "supplements", that are, in all effect, completely untested (for efficacy and safety). I'm fairly concerned that there are serious health risks associated with these substances. Maybe this is an old topic of debate, but after reading so many posts about claimed adverse affects from supplements, it kind of gets me thinking.
Does anyone REALLY know WTF even half of these supplements are doing to us in the short-term? Long-term? Short-term, maybe. Long-term, highly doubtful. Sometimes I just think it's stupid that we're jamming all these chemicals into ourselves, blowing wads of money, then reaping a few measly pounds of muscle (if any!). All the while, we may be destorying our livers, kidneys, heart (thermos!), etc.
...
Link #26: (http://anabolicminds.com/forum/575501-post96.html) Hustled?
Well founded points. Risk/reward is skewed. However, I don't think you need to take it to the extreme of anabolic steroids or other illegal supplementation. There are many other time test substances on the market (why protein, creatine monohydrate). Because most of us here demand so much of ourselves, we push what we put in our bodies. This plays into the hands of many supplement providers.
I'm not saying that all supplement providers nor all CEE providers have opportunistic intentions. But many of us curse our lawmakers for taking away a whole class of supplements (PHs) for the purpose of protecting a minority that refused to educate and safeguard itself, while we do the exact such thing with supplements such as CEE. If we provide lip service to the idea of self-regulation, then we should not be surprised when such a privilege is taken away from us. Unfortunately, widespread cynicism is the key. We can't take it for granted when a supplement provider's information regarding the safety of their product is based on an entirely different compound, as it is with CEE. Saying Creatine Ethyl Ester is safe because it is made from Creatine Monohydrate is like saying methanphetamine is safe because it is made from sudafed. IMHO, of course.
Link #27: (http://anabolicminds.com/forum/574727-post91.html) The Clincher.
As I've stated numerous times, I'm no chemist. So you won't find me trying to dicipher the esoteric terminology used in the patent. However, it is clear that the methodology used is based on a previously disproved paper. The patent references and draws heavily on the previous work of Dox and Yoder and their 1922 paper The Esterfication of Creatine. One such example is the following paragraph:
Although the formulation of creatine ethyl ester is disclosed, it should be apparent that a variety of creatine esters may be produced utilizing analogous reaction systems without departing from the spirit and scope of the present invention. See Dox., A.W.; Yoder, L. Esterifcation of Creatine. J. Biol. Chem. 1922, 67,671-673, 20 which is herein incorporated by reference in its entirety. For instance, a variety of methods of producing a creatine ester are contemplated without departing from the spirit and scope of the present invention, such as the methods aud process shown in FIG. 4, wherein X may include a leaving group. Although the use of creatine monohydrate is disclosed, a variety of creatine containing starting compounds are 25 contemplated by the present invention, creatine monohydrate being disclosed merely because of its availability.
The problem lies in the fact that Dox and Yoder were proven wrong over fifty years ago. Dox and Yoder claimed to create creatine ethyl ester but it was proven to be just creatinine. The paper I linked to earlier (Creatine Ethyl Ether BY JAMES D. MOLD, ROBERT C. GORE, JOSEPH M. LYNCH AND E. J. SCHANTZ) itself dismantles Dox and Yoder's work as well as references others who have as well. Here are snippets:
Kapfhammer repeated the preparation of several of these compounds and confirmed the findings of Dox and Yoder. He pointed out, however, that the behavior of these compounds in chemical reactions and toward colorimetric tests and precipitating agents was typical of creatinine and not of creatine.
More.........
Farlane later showed ........ when the chloride was re-moved by shaking creatine methyl ester hydro-chloride with silver carbonate prior to the nitrous acid treatment, only 41y0 of the total nitrogen was evolved, suggesting that a conversion to creatinine may have occurred. Failey and Brand, upon careful electrometric titration of creatine methyl ester hydrochloride with sodium hydroxide, noted an irreversible conversion during the titration, with the end-product giving a titration curve identical to creatinine.
So, I know people will continue using and buying CEE, but I'm quite satisfied that it is bunk now. I have no doubt that the esterfication of creatine would be a boon and would be theoretically superior, but it just doesn't seem to actually have been executed. The fact that the University of Nebraska is involved doesn't impress me either. That's not me being an Ivy League snob, that's me knowing that academics are incredibly fallable. There is a lot to be gained from fudging your lab results.
Overall, given what the patent application contained, I'm not surprised that it was rejected. But does anyone know the exact reason stated for its rejection? I mean, CreaTate is based on dubious science as well, yet it was approved for a patent. How unsubstantiated does something have to be to be outright rejected?
The amount of negative reactions are not limited to the ones I linked to; I only linked to ones that I felt provided the most compelling insight to the individual's case.
Please realize that I'm not saying Creatine Monohydrate is fake, but rather that it is possible that CEE is. With so many people not only on this forum, but in the rest of the health/fitness population in general, I think that if indeed CEE proves to be fake, it could be one of the biggest scams in the history of marketing. Think of what it could mean: kidney problems encountered on a grand scale. That, most definitely, would not be good.
So what do you think? :read::flex: